TABLE 3.
Changes in kidney and brain CFU per gram of tissue for each treatment group compared to fungal burden measured prior to the start of therapy (24-h control) and in the vehicle control group on day 8 postinoculation
| Treatment group | Log10 change in: |
|||
|---|---|---|---|---|
| Kidney CFU/g vs. 24-h control (95% CIa ) | Kidney CFU/g vs. vehicle control (95% CI) | Brain CFU/g vs. 24-h control (95% CI) | Brain CFU/g vs. vehicle control (95% CI) | |
| Vehicle control | 2.06 (3.90 to 0.23) | 1.29 (0.31 to 2.29) | ||
| VT-1598, 5 mg/kg | 0.91 (−0.92 to 2.74) | −1.15 (−2.66 to 0.34) | 0.23 (−0.75 to 1.22) | −1.06 (−1.87 to −0.25) |
| VT-1598, 15 mg/kg | 0.18 (−1.65 to 2.02) | −1.88 (−3.38 to −0.39) | −0.3 (−1.29 to 0.69) | −1.59 (−2.40 to −0.78) |
| VT-1598, 50 mg/kg | −1.55 (−3.38 to 0.29) | −3.61 (−5.11 to −2.11) | −0.86 (−1.85 to 0.13) | −2.15 (−2.96 to − 1.34) |
| Fluconazole, 20 mg/kg | 1.26 (−0.56 to 3.10) | −0.8 (−2.30 to 0.70) | 1.11 (0.12 to 2.10) | −0.18 (−0.99 to 0.62) |
| Caspofungin, 10 mg/kg | −2.03 (−3.86 to −0.19) | −4.09 (−5.59 to −2.60) | −0.06 (−1.04 to 0.94) | −1.35 (−2.16 to −0.54) |
a
CI, confidence interval.