Table I.
Effects of Cilostazol on serum albumin, globulin and A/G in rats.
| Measurement | Control | Model | Colchicine | Cilostazol (5 mg/kg) | Cilostazol (10 mg/kg) | Cilostazol (20 mg/kg) | Cilostazol-only (10 mg/kg) |
|---|---|---|---|---|---|---|---|
| Albumin (g/l) | 41.2±6.5 | 40.3±5.5 | 40.6±5.4 | 41.6±4.3 | 40.7±4.7 | 41.1±3.9 | 40.3±5.4 |
| Globulin (g/l) | 38.2±4.2 | 63.5±4.8 | 43.1±4.9 | 60.3±5.1 | 47.6±3.9 | 45.1±4.3 | 39.9±4.9 |
| A/G | 1.08±0.11 | 0.63±0.08a | 0.94±0.12b | 0.69±0.07 | 0.86±0.08b | 0.91±0.07b | 1.12±0.15 |
Control, rats received no treatment; Model, rats received oral alcohol infusions to induce liver fibrosis; Colchicine, rats received oral alcohol and colchicine (0.1 mg/kg/day); Cilostazol (5, 10 or 20 mg/kg), rats received oral alcohol and cilostazol at 5, 10 or 20 mg/kg/day; Cilostazol-only (10 mg/kg), rats received oral cilostazol at 10 mg/kg/day. Data are presented as the mean ± standard deviation (n=20/group).
a
P<0.05 vs. Control
b
P<0.05 vs. Model. A/G, albumin/globulin.