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(a) Bone volume percentage38 and (b) microstrain of the system under mechanical stimuli. Note that in (b), HBC (healthy small and large load-bearing bones) should satisfy this criterion (MESr, MESm); MESr: 50–100 μm, disusing strain window representing the reduction of bone mass; MESm: 100–1000 μm, healthy strain window representing the increase in bone mass.21
