Figure 1: Mortality in Natriuretic Peptide Guided Trials in Chronic Heart Failure with Reduced Ejection Fraction.

Forest plot of mortality among participants in natriuretic peptide (NP) guided trials in chronic HFrEF, showing unadjusted individual and mean hazard ratios with 95% confidence intervals (CIs) for 12 studies (individual patient data in eight studies — Troughton, et al. 2000;[33], Pfisterer, et al. 2009;[36] Berger et al. 2010;[37] Eurlings, et al. 2010;[38] Lainchbury, et al. 2010;[39] Persson, et al. 2010;[40] Januzzi, et al. 2011;[41] Karlstrom, et al. 2011;[42]) and aggregate data in four studies (Felker, et al. 2017;[29] Beck-da-Silva, et al. 2005;[34] Jourdain, et al. 2007;[35] Shah, et a. 2011[33]).