Figure 4.

Oxcarbazepine inhibits stimulus‐evoked and spontaneous firing of thalamic WDR neurones in SNL rats. Neuronal responses to punctate mechanical (a), heat (b), cold (c), dynamic brush (d) stimuli, and spontaneous single spike (e) and burst (f) firing rates, prior to and following systemic administration of oxcarbazepine (30 mg/kg). Histogram and event mark traces represent typical single‐unit responses. Event markers (EM) indicate the time point of spike upstroke, and burst markers (BM) signify individual burst events. Data represent mean ± 95% CI, n = 9 neurones from 7 rats. Asterisks (*) denote difference from baseline; *p < 0.05, **p < 0.01. (Ac, acetone; Ec, ethyl chloride)