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. 2019 Jan 4;38(5):e100276. doi: 10.15252/embj.2018100276

Figure 5. The disome interface and location of ubiquitination sites.

Figure 5

  • A
    Overview of the contact interface. The thumbnail on top indicates the orientation.
  • B–E
    Zoom views on the 40S head‐to‐head contact site (B), the 40S platform‐to‐platform contact site (C), the 40S body‐to‐body contact site (D) and the 60S‐to‐40S contact site (E). In (D), nucleotides missing in the model at the tip of ES6c are indicated by a dashed line.
  • F
    Location of uS3 (K212) and uS10 (K6 and K8) ubiquitination sites. All ubiquitination sites are in the close spatial vicinity highlighted with red spheres. RACK1 proteins from both the leading and the colliding ribosome form the major head‐to‐head contact bringing together both C‐terminal tails of uS3s and N‐termini of uS10s. For the uS10 ubiquitination sites, only an approximate position is shown as indicated by dashed lines since the uS10 N‐termini containing K6 and K8 are invisible in the structure most likely due to flexibility.