Expression level of circLPAR1 in MIBC tissues and survival curve of DSS for 125 patients. (A) Expression level of cirLPAR1 was significantly reduced in 68 MIBC tissues, compared with para-carcinoma tissues (P=0.00002). (B) There was significant difference in DSS between patients with a low circRNA expression level and a high circRNA expression level (52.4 vs. 56.0 months; P=0.001). MIBC, muscle-invasive bladder cancer; circRNA, circular RNA; LPAR1, lysophosphatidic acid receptor 1; DSS, disease specific survival.