Table II.
Univariate and multivariate Cox regression analyses for disease-specific survival in 125 patients with muscle-invasive bladder cancer.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Variables | P-value | HR (95% CI) | P-value | HR (95% CI) |
| Age (years) | ||||
| <61 vs. ≥61 | 0.910 | 0.968 (0.548–1.710) | ||
| Sex | ||||
| Male vs. female | 0.266 | 0.614 (0.260–1.451) | ||
| Pathological T stagea | ||||
| T2 vs. T3+T4 | 0.008 | 2.176 (1.228–3.857) | 0.027 | 1.885 (1.040–3.416) |
| Pathological N stagea | ||||
| N0 vs. N1+N2 | 0.070 | 1.780 (0.955–3.318) | ||
| Pathological Grade | ||||
| Low vs. high | 0.021 | 2.598 (1.154–5.851) | 0.042 | 2.355 (1.031–5.380) |
| Maximum tumor diameter (cm) | 0.089 | 1.682 (1.040–3.416) | ||
| <3.5 vs. ≥3.5 | 0.015 | 2.041 (1.149–3.626) | ||
| Tumor number (n) | ||||
| 1 vs. ≥2 | 0.403 | 0.762 (0.403–1.441) | ||
| circLPAR1 level | ||||
| Low vs. highb | 0.001 | 0.364 (0.197–0.673) | 0.011 | 0.444 (0.237–0.832) |
| Recurrence after TURBT | ||||
| Yes vs. no | 0.356 | 1.351 (0.713–2.558) | ||
| Chemotherapy before radical cystectomy | ||||
| Yes vs. no | 0.19 | 1.466 (0.828–2.596) | ||
a
According to the 2002 6th edition of the Union for International Cancer Control Tumor-Node-Metastasis staging system.
b
The low level of circLPAR1 expression was defined the level less than the median value (2−∆∆Cq=0.0023), and the high level was defined as the level equal or more than the median value. TURBT, transurethral resection of bladder tumor; DSS, disease-specific survival; circLPAR1, circular lysophosphatidic acid receptor 1; HR, hazard ratio; CI, confidence interval.