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Effect of cisplatin, celastrol or a combination on the viability of U-2OS cells. (A) Dose- and time-effect of cisplatin on the viability of U-2OS cells. (B) Dose- and time-effect of celastrol on the viability of U-2OS cells. (C) The viability of U-2OS cells following treatment with celastrol and cisplatin at each concentration for 48 h. (D) The combination index. Data are expressed as means ± standard deviation. *P<0.05, **P<0.01, ***P<0.001 vs. control (0 µM). fa, fraction affected.
