Table 2.
Conditional analysis results for FVII activity using the trans-ancestry meta-analysis results
| rsID | Chr:Pos* | Alleles† | Freq‡ | β§ | P§ | Joint β|| | Joint P|| | Variance explained, %¶ |
|---|---|---|---|---|---|---|---|---|
| F7 | ||||||||
| rs117989138 | 13:113697671 | A/G | 0.02 | 0.086 | 3.6 × 10−22 | 0.081 | 8.7 × 10−20 | 0.6 |
| rs36086577 | 13:113728498 | C/A | 0.87 | 0.035 | 2.2 × 10−19 | 0.031 | 7.5 × 10−15 | 0.6 |
| rs71446935 | 13:113734376 | A/G | 0.31 | 0.035 | 5.5 × 10−38 | 0.032 | 5.1 × 10−31 | 1.2 |
| rs1046205 | 13:113752057 | A/T | 0.79 | 0.121 | 3.9 × 10−573 | 0.121 | <1.0 × 10−320 | 12.1 |
| PROCR | ||||||||
| rs6119569 | 20:33672371 | G/A | 0.78 | 0.022 | 8.8 × 10−17 | 0.019 | 3.9 × 10−13 | 0.3 |
| rs867186 | 20:33764554 | G/A | 0.10 | 0.057 | 3.3 × 10−64 | 0.055 | 8.1 × 10−59 | 1.4 |
The variance explained shown in this table was calculated using the sample size weighted mean variance of log-transformed FVII and the betas and frequencies from the trans-ancestry meta-analysis summary statistics.
Abbreviations are explained in Table 1.
The Chr:Pos column shows the chromosome and position (build 37).
The Alleles column shows the FVII-increasing allele/FVII-decreasing allele.
The Freq column shows the frequency of the FVII-increasing allele.
The β and P columns are based on the association of each variant in isolation.
The Joint β and Joint P columns are based on the association of each variant test conditioned on the other variants.
The Variance Explained column is based on the joint analysis.