Figure 1.

Mutational landscape of mnBLL,11q, showing recurrent GNA13 mutations. (A) Depicted are the potentially protein-changing SNVs and indels. Columns encode samples and rows different genes. Different mutation types are color-coded in the oncoprint, where different types of mutation can coexist in 1 sample. *Mutations within these genes are considered as dubious hits as reported by Lawrence et al.¹⁵ (B) Overall, the mutational profile differs between the 2 lymphoma entities, and only a few genes are frequently mutated in both including GNA13 and DDX3X. Included are those genes that are mutated in ≥4 of 15 mnBLL,11q, cases and the 13 genes recurrently mutated in >6 of 39 (>15%) BL cases (median age at diagnosis 8 years [range, 2-18 years]) based on whole-genome sequencing data accessible at www.icgc.org.