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. 2019 Jan 21;17(3):3151–3162. doi: 10.3892/ol.2019.9951

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Copyright: © Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Effect of nintedanib on tumor volumes, and CDC42 and E-cadherin expression levels in mouse xenografts. (A) Growth curves for xenografts in each group. *P<0.05 vs. control (two-way ANOVA followed by Bonferroni post hoc tests). (B) Quantitative immunohistochemistry analysis and representative microscopic fields for CDC42 and E-cadherin staining (magnification, ×200). The expression of CDC42 decreased, whereas the expression of E-cadherin increased in nintedanib-treated mice, compared with controls. **P<0.01 vs. control (Student's t-test). CDC42, cell division cycle 42; E-cadherin, epithelial cadherin.