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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Mod Pathol. 2018 Jun 8;31(10):1608–1618. doi: 10.1038/s41379-018-0079-6

Figure 1.

Figure 1.

A. Solitary non-neoplastic colonic crypt with loss of MSH6 protein expression by immunohistochemistry (black arrow) in a patient with Lynch syndrome due to a pathogenic germline variant in MSH6 (MSH6 immunohistochemistry, 200x magnification) (Table 2, case 4). B. Non-neoplastic colonic mucosa in another patient with Lynch syndrome due to a pathogenic germline variant in MSH6 (Table 2, case 3) (H&E stain, 100x magnification). C. The non-neoplastic colonic mucosa depicted in B (Table 2, case 3) harbored a group of colonic crypts demonstrating loss of MSH6 protein expression by immunohistochemistry (MSH6 immunohistochemistry, 100x magnification).