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A. Original immunohistochemical stain for MLH1 demonstrated preserved expression in all non-neoplastic colonic crypts (Table 2, case 18) in a Lynch syndrome patient with a pathogenic germline variant in MLH1 (MLH1 immunohistochemistry, 40x magnification). B. A deeper section (80 μm deeper) reveals a single crypt with loss of MLH1 expression by immunohistochemistry (black arrow) (MLH1 immunohistochemistry, 40x magnification).
