Table 2.

Patients with DNA Mismatch Repair (MMR) Protein Deficient Non-Neoplastic Colonic Crypts

Case Number	Tumor MMR Protein Expression Pattern by IHC	Germline MMR Gene Affected	Age at Diagnosis (years)	Gender	Linear Length of Non-Neoplastic Colonic Mucosa Evaluated (mm)	Estimated Number of Non-Neoplastic Colonic Crypts Evaluated	MMR Protein Evaluated in Non-neoplastic Mucosa by IHC	Number of MMR Deficient Non-Neoplastic Colonic Crypts by IHC	Location of MMR Deficient Non-Neoplastic Colonic Crypts	Pattern of MMR Deficient Non-Neoplastic Colonic Crypts (Solitary vs. Grouped)
1	MSH2/MSH6 loss	MSH2	65	Female	145	1611	MSH2	13	Center colon	Solitary and Grouped
2	MSH2/MSH6 loss	MSH2	55	Male	131	1456	MSH2	1	Right colon	Solitary
3	Isolated MSH6 loss	MSH6	66	Male	180	2000	MSH6	49	Center colon	Grouped
4	Isolated MSH6 loss	MSH6	48	Male	102	1133	MSH6	1	Right colon	Solitary
5	Isolated PMS2 loss	PMS2	52	Male	158	1756	PMS2	1	Center colon	Solitary
6	MLH1/PMS2 loss	MLH1	49	Male	61	678	MLH1	1	Center colon	Solitary
7	Isolated PMS2 loss	PMS2	79	Male	167	1856	PMS2	5	Right colon	Grouped
8	Isolated PMS2 loss	PMS2	71	Female	118	1311	PMS2	1	Right colon	Solitary
9	MSH2/MSH6 loss	MSH2	34	Female	171	1900	MSH2	4	Right colon	Grouped
10	Isolated MSH6 loss	MSH6	65	Female	199	2211	MSH6	2	Right colon	Solitary
11	MSH2/MSH6 loss	MSH2	27	Female	90	1000	MSH2	6	Right colon	Grouped
12	MLH1/PMS2 loss	MLH1	60	Female	21	233	MLH1	8	Right colon	Grouped
13	MSH2/MSH6 loss	MSH2	53	Female	62	688	MSH2	1	Right colon	Solitary
14	MLH1/PMS2 loss	MLH1	64	Male	101	1117	MLH1	2	Right colon	Solitary
15	MSH2/MSH6 loss	MSH2	47	Female	56	624	MSH2	3	Right colon	Solitary
16	Isolated MSH6 loss	MSH6	73	Male	269	2989	MSH6	2	Right colon	Solitary
17	MSH2/MSH6 loss	MSH2	40	Female	336	3733	MSH2	4	Right colon	Grouped
18	MLH1/PMS2 loss	MLH1	69	Female	76	844	MLH1	1	Right colon	Solitary
19	MSH2/MSH6 loss	None	47	Male	80	889	MSH2	2	Right colon	Solitary

MMR, mismatch repair; IHC, immunohistochemistry