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. Author manuscript; available in PMC: 2019 Aug 4.
Published in final edited form as: Nat Immunol. 2019 Feb 4;20(3):313–325. doi: 10.1038/s41590-018-0296-7

Fig. 2. NMT1 controls proinflammatory T cell differentiation.

Fig. 2.

CD4+CD45RA+ T cells from patients with RA and age-matched healthy individuals were stimulated for 72 h. Lineage-determining transcription factors (T-bet, RORγt, GATA-3) were analyzed 4 days after stimulation. IFN-γ and IL-17 were measured by intracellular cytokine staining on day 6. Neutral lipid droplets were detected with BODIPY 493/503. (a-f) CD4+ T cells from RA patients were transfected with an NMT1 expression vector or a control vector. Data (mean ± SEM) from 6 RA patients compared by paired Mann-Whitney-Wilcoxon rank test. (g-l) CD4+ T cells from healthy individuals were transfected with NMT1 siRNA or control siRNA. Data (mean ± SEM) from 6 healthy donors. Paired Mann-Whitney-Wilcoxon rank test. *p < 0.05.