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. 2018 Apr 10;154:66–86. doi: 10.1016/j.antiviral.2018.04.004

Fig. 12.

Fig. 12

Structure of the 2′-deoxy non-obligate chain terminator Entecavir that features a unique exocyclic double bond which leads to unfavorable steric interactions resulting in chain termination despite the presence of a 3′-OH.