Fig. 4.

(A) AD dementia onset ages predicted using the linear regression model with PS + age vs. observed AD dementia onset age (for individuals with known onset ages in the testing set). Time between baseline age and AD onset age (indicated by the size of the markers) varied between 0.48 and 9.0 years (median 1.6, IQR 1.0-3.0). There were 18, 15, 10, and 3 participants whose true time to diagnosis was in the interval $(0.4,1.5)$, $(1.5,2.5)$, $(2.5,5.0)$, and $\left(\mathrm{5,9.1}\right)$, respectively. The RMSEs corresponding to these ranges were 1.64, 1.06, and 0.84, 3.14. (B) Kaplan-Meier curves based on observed (red) and predicted (blue) AD dementia onset ages.