Figure 2.

Domain architecture of Ras-specific GTPase-activating proteins (RasGAPs). Representative RasGAPs are schematically shown with emphasis on their domain structure. Red boxes indicate GAP-(related) domains (GRDs). Sec14 represented in orange, src homology (SH, bronze), pleckstrin homology (PH, blue). Other domains like Ca²⁺-dependent phospholipid-binding/conserved region 2 (C2), isoleucine-glutamine repeat region (IQ), WW (conserved tryptophan), calponin homology (CH), juxtamembrane (JM), transmembrane (TM), and extracellular (EC) domains are also shown.