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. 2019 Jan 17;3(3):392–405. doi: 10.1002/hep4.1303

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© 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Liver cirrhosis stage‐dependent excess of IL‐22BP. (A) IL‐22BP serum concentrations are shown according to the indicated stage of liver cirrhosis. (B) The ratio of serum concentrations of IL‐22BP divided through serum concentrations of IL‐22 (shown in Fig. 1) were calculated and compared among patients with the indicated stages of liver cirrhosis. Significantly lower ratios of IL‐22BP/IL‐22 are observed in patients with decompensated liver cirrhosis and ACLF compared with patients with compensated liver cirrhosis or healthy controls. (C) IL‐22BP concentrations were quantified at baseline and compared between patients who died or who survived until day 28 of follow‐up. (D) The ratio of serum concentrations of IL‐22BP divided through serum concentrations of IL‐22 were calculated and compared between patients who died or who survived until day 28 of follow‐up. (E) The ratio of IL‐22BP to IL‐22 serum concentration is associated with liver synthesis capacity. The ratio of serum concentrations of IL‐22BP divided through serum concentrations of IL‐22 were calculated in all patients with liver cirrhosis and correlated with INR (left panel) and with serum albumin concentration (right panel). Abbreviations: comp., compensated; decomp., decompensated; and gr., grade.