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. 2019 Jan 17;3(3):392–405. doi: 10.1002/hep4.1303

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© 2019 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Ability of patient serum to induced hepatocellular IL‐22 signaling depends on the IL‐22BP/IL‐22 ratio. Huh‐7 cells were incubated with representative serum samples of patients with low and high IL‐22BP/IL‐22 ratios for 15 minutes. (A) Western blot analyses for the indicated antigens were performed. IL‐22BP and IL‐22 concentrations as well as IL‐22BP/IL‐22 ratios of the patient samples are shown. (B) Cells were pretreated with or without a neutralizing antibody against the IL‐22 receptor before exposure to patient serum with high IL‐22 activity (1 and 2 from [A]) for 15 minutes.