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. 2019 Mar;29(3):325–333. doi: 10.1101/gr.241745.118

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© 2019 Wang and Lemos; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 4. — The ribosomal rDNAm clock is conserved between distantly related taxa. (A) Phylogenetic tree of seven vertebrate species with the number of homologous CpGs in each species (relative to human). (B) Interspecific mouse-canid clock models built using homologous CpGs in the rDNA yielded significantly better performance than those built using homologous genome-wide CpGs. Here, the model is trained in one species and applied to the other species. The fit is measured as the correlation coefficient (ρ) between rDNAm age and chronological age in the testing species. (C) Homologous CpGs from the rDNA show conserved age association (ρ_age) between mice and canids (ρ = 0.49, P = 1.88 × 10⁻⁶). (D) Homologous CpGs elsewhere in the genome show age association that is weakly correlated between mice and canid (ρ = 0.09, P = 7.01 × 10⁻¹⁶).