Figure 2.

Silence of MALAT1 suppressed osteosarcoma cell proliferation, migration, and invasion. (A) MG-63 cells were transfected with MALAT1 siRNA, and siRNA control. Relative expression of MALAT1 was assessed using qRT-PCR. (B) CCK-8 assay was performed to evaluate the effect of MALAT1 on cell proliferation. (C) Wound-healing assay showed that silence of MALAT1 significantly suppressed osteosarcoma cell migration capacity. (D) Matrigel invasion assay showed that silence of MALAT1 significantly inhibited osteosarcoma cell invasion capacity. Data are presented as mean ± standard deviation for 3 independent experiments. * P<0.05, ** P<0.01 compared with siRNA control.