Table.

Summary of individual patient data associations between serum biochemistry and adverse perinatal outcome for singleton pregnancies

	Bile acids		Alanine aminotransferase		Aspartate aminotransferase		Bilirubin
	n/N (%)	ROC AUC (95% CI)	n/N (%)	ROC AUC (95% CI)	n/N (%)	ROC AUC (95% CI)	n/N (%)	ROC AUC (95% CI)
Stillbirth	25/4269 (1%)	0·83 (0·74–0·92)	22/3668 (1%)	0·46 (0·35–0·57)	17/3071 (1%)	0·49 (0·36–0·62)	13/2425 (1%)	0·57 (0·42–0·72)
Preterm birth	1256/4378 (29%)	0·60 (0·58–0·63)	583/1836 (32%)	0·55 (0·52–0·57)	583/1836 (32%)	0·54 (0·51–0·57)	583/1836 (32%)	0·57 (0·54–0·60)
Spontaneous preterm birth	383/4316 (9%)	0·61 (0·58–0·64)	141/1791 (8%)	0·59 (0·54–0·64)	141/1791 (8%)	0·59 (0·54–0·65)	141/1791 (8%)	0·57 (0·51–0·62)
Iatrogenic preterm birth	817/4316 (19%)	0·58 (0·55–0·60)	397/1791 (22%)	0·53 (0·50–0·56)	397/1791 (22%)	0·52 (0·50–0·55)	397/1791 (22%)	0·56 (0·53–0·59)
Meconium stained amniotic fluid	588/4032 (15%)	0·62 (0·59–0·64)	243/1605 (15%)	0·59 (0·55–0·63)	243/1605 (15%)	0·59 (0·56–0·63)	243/1605 (15%)	0·57 (0·53–0·61)
Non-reassuring heart rate monitoring	588/3057 (19%)	0·58 (0·55–0·60)	192/1379 (14%)	0·50 (0·46–0·55)	192/1379 (14%)	0·53 (0·49–0·58)	192/1379 (14%)	0·54 (0·49–0·58)
Apgar score <7 at 5 min	90/4181 (2%)	0·65 (0·58–0·71)	32/1698 (2%)	0·45 (0·36–0·54)	32/1698 (2%)	0·49 (0·40–0·58)	32/1698 (2%)	0·51 (0·40–0·62)
Umbilical cord arterial blood pH <7·0	1/2029 (1%)	0·68 (0·53–0·82)	6/630 (1%)	0·48 (0·21–0·76)	6/630 (1%)	0·49 (0·22–0·75)	6/630 (1%)	0·52 (0·23–0·81)
Neonatal unit admission	798/4014 (20%)	0·55 (0·52–0·57)	182/1533 (12%)	0·57 (0·53–0·62)	182/1533 (12%)	0·58 (0·54–0·63)	182/1533 (12%)	0·55 (0·51–0·60)
Neonatal death	7/2888 (<1%)	0·62 (0·38–0·86)	5/1391 (<1%)	0·56 (0·31–0·84)	5/1391 (<1%)	0·62 (0·38–0·87)	5/1391 (<1%)	0·68 (0·53–0·84)

ROC AUC=receiver operating characteristic area under curve.