Table 4.

Differentially methylated regions in blood DNA in relation to PM₁₀ exposure (adjusted P < 0.05 both in DMRcate and in comb-p)

Chra	Gene (distance to geneb)	DMRcate				comb-p				Minimum Pg
		Start (bpc)	End (bp)	FDRd	#CpGse	Start (bp)	End (bp)	Sidak Pf	#CpGs
1	MIB2	1549615	1550031	0.020	5 (4)			0.009		0.009
2	NOL10 (−22,166)	10687583	10688726	9.4E-05	8 (5)	10687962	10688317	2.6E-05	5 (5)	2.5E-04
2	SNED1	241975035	241976244	0.006	6 (5)	241975756		0.015	4 (4)	0.005
3	IL20RB	136676672	136676846	0.007	2 (2)			0.011		2.5E-04
6	TRIM27	28874479	28875370	9.4E-05	7 (6)		28874754	7.3E-04	4 (4)	0.002
6	TRIM39	30297174	30297627	2.3E-08	11 (10)			1.1E-07		8.4E-04
6	LTA	31539539	31540750	1.3E-11	19 (13)		31540461	3.4E-06	18 (12)	4.8E-05
6	TREM1	41254471	41254997	0.018	4 (3)	41254433		0.012	5 (3)	1.7E-04
7	FOXK1	4752951	4753002	1.3E-04	3 (3)			7.2E-04		3.4E-04
8	CSGALNACT1	19459672	19460243	0.003	7 (4)			0.001		7.8E-04
8	PIWIL2	22131675	22133356	1.2E-04	15 (6)	22132563		0.027	13 (5)	3.8E-05
8	KIF13B h	28961315	28961356	2.9E-04	3 (2)			0.003		1.4E-06
9	C9orf131	35042344	35042395	0.003	2 (2)			0.005		5.6E-05
10	CAMK1D	12648032	12648338	3.6E-02	3 (2)		12648526	0.011	4 (3)	0.002
10	C10orf105	73498624	73498766	0.003	3 (2)			0.032		2.7E-05
10	PTPRE	129794994	129795003	0.002	2 (2)			0.020		3.9E-05
15	FLJ42289	100890907	100891257	1.1E-04	5 (4)	100890963		0.014	4 (3)	8.8E-05
17	TNRC6C	76036514	76037562	7.3E-05	7 (7)	76037035		1.6E-05	6 (6)	0.001
17	CCDC57	80084554	80085082	1.3E-04	4 (4)			1.3E-05		4.3E-05
19	PRTN3	846117	846354	0.010	3 (3)			0.004		0.001
19	PRTN3	847943	848071	0.005	4 (4)			0.003		0.001
19	CALR	13053719	13054718	0.002	5 (4)	13054427		0.014	4 (3)	8.3E-05
19	FBXO17	39465821	39466757	0.002	8 (4)			0.004		6.6E-04
20	STK35	2085157	2085344	0.003	2 (2)			0.002		1.7E-05
20	SLPI	43882990	43883307	0.004	3 (3)		43883546	8.5E-04	4 (4)	9.7E-04
20	C20orf123	45179157	45179413	2.0E-04	6 (5)			1.4E-04		2.2E-04
21	C21orf81	15352848	15352983	0.013	2 (2)			0.012		4.7E-04

Blanked cells in “Start,” “End,” and “#CpGs” for comb-p represent the same information compared to results in DMRcate

^aChromosome

^bMinimum distance to transcription start site of the mapped gene (base pair)

^cPhysical position (base pair, National Center for Biotechnology Information human reference genome assembly Build 37.3)

^dBenjamini-Hochberg false discovery rate

^eNumber of probes in the region (number of probes having uncorrected p value < 0.05)

^fP of Sidak multiple-testing correction

^gMinimum p value among uncorrected p-values of CpGs in each region. When either start or end positions were different between DMRs from the two DMR approaches, we used results from DMRcate

^hRegion including significant (FDR < 0.05) differentially methylated probes from our epigenome-wide association study