Table 3.
Associations of genetic variants of HOTAIR with PC risk in Stage 2 and combined results
| Genotype | Cases | Controls | Crude OR (95% CI) | Adjusted OR (95% CI)a |
|---|---|---|---|---|
| rs4759314 | ||||
| Stage 2 | ||||
| AA | 406 | 437 | 1.00 (reference) | 1.00 (reference) |
| AG | 83 | 59 | 1.51 (1.06–2.17) | 1.57 (1.08–2.29) |
| GG | 11 | 4 | 2.96 (0.99–8.89) | 3.08 (1.04–9.13) |
| G vs A | 1.63 (1.19–2.24) | 1.7 (1.23–2.36) | ||
| P trend | 0.023 | 0.017 | ||
| Combined | ||||
| AA | 733 | 791 | 1.00 (reference) | 1.00 (reference) |
| AG | 148 | 103 | 1.55 (1.18–2.03) | 1.61 (1.22–2.13) |
| GG | 19 | 6 | 3.42 (1.43–8.16) | 3.55 (1.51–8.36) |
| G vs A | 1.69 (1.33–2.15) | 1.76 (1.37–2.25) | ||
| P trend | 0.001 | 0.001 | ||
| rs200349340 | ||||
| Stage 2 | ||||
| GG | 264 | 295 | 1.00 (reference) | 1.00 (reference) |
| TG | 196 | 175 | 1.25 (0.96–1.63) | 1.30 (0.97–1.74) |
| TT | 40 | 30 | 1.49 (0.9–2.45) | 1.54 (0.92–2.61) |
| T vs G | 1.24 (1.01–1.52) | 1.29 (1.03–1.62) | ||
| P trend | 0.094 | 0.027 | ||
| Combined | ||||
| GG | 469 | 531 | 1.00 (reference) | 1.00 (reference) |
| TG | 357 | 315 | 1.28 (1.06–1.56) | 1.33 (1.07–1.65) |
| TT | 74 | 54 | 1.55 (1.07–2.25) | 1.61 (1.10–2.37) |
| T vs G | 1.27 (1.09–1.47) | 1.32 (1.12–1.56) | ||
| P trend | 0.013 | 0.001 | ||
aAdjusting for age, gender, diabetes, drinking and smoking
Italic values indicate significant of p value (P<0.05)