Table I.
Baseline characteristics by individualized AMH-based or standard dosing.
| Type of dosing | ||
|---|---|---|
| Individualized | Standard | |
| N = 149 | N = 72 | |
| Age (y), mean ± SD | 32.2 ± 3.3 | 31.6 ± 3.2 |
| Age groups, N (%) | 29 (19.5) | 21 (29.2) |
| <30 | 74 (49.7) | 37 (51.4) |
| 30–34 | ||
| 35–38 | 46 (30.9) | 14 (19.4) |
| BMI (kg/m2), mean ± SD | 22.2 ± 4.1 | 22.0 ± 2.6 |
| Duration of infertility (months), mean ± SD | 27.3 ± 13.0 | 27.1 ± 10.3 |
| Main cause of infertility, N (%) | ||
| Male | 75 (50.3) | 45 (62.5) |
| Tubal | 14 (9.4) | 4 (5.6) |
| Combined factors | 4 (2.7) | 1 (1.4) |
| Unexplained | 56 (37.6) | 22 (30.6) |
| Primary infertility, N (%) | 103 (69.1) | 54 (75.0) |
| Cycle length (d), mean ± SD | 28.2 ± 1.8 | 28.1 ± 1.9 |
| Ovarian volume (mL), mean ± SD | 6.1 ± 2.6 | 6.2 ± 2.8 |
| AFC, mean ± SD | 20.3 ± 7.3 | 19.3 ± 7.5 |
| AMH (pmol/L)*, median (IQR) | 16.8 (12.0–23.0) | 15.2 (10.6–23.5) |
| FSH (IU/L), median (IQR) | 7.5 (6.2–8.9) | 7.2 (6.1–8.4) |
| Treatment groups by AMH, N (%) | ||
| AMH 4–11.9 | 33 (22.1) | 20 (27.8) |
| AMH 12–23.9 | 81 (55.4) | 34 (47.2) |
| AMH 24–40 | 35 (23.5) | 18 (25.0) |
| Pretreatment stimulation characteristics by AMH stratum | ||
| AMH 4–11.9 pmol/L | ||
| AMH, median (IQR) | 9.6 (6.6–10.7) | 8.8 (6.6–9.6) |
| FSH, median (IQR) | 7.8 (6.5–9.2) | 7.2 (6.8–8.6) |
| AFC, mean ± SD | 14.3 ± 4.8 | 12.9 ± 3.9 |
| AMH/AFC | 0.64 ± 0.18 | 0.68 ± 0.27 |
| AMH 12–23.9 pmol/L | ||
| AMH, median (IQR) | 16.8 (13.6–20.0) | 15.6 (13.0–20.0) |
| FSH, median (IQR) | 7.3 (6.2–9.0) | 7.2 (6.2–8.8) |
| AFC, mean ± SD | 19.7 ± 5.4 | 19.7 ± 6.0 |
| AMH/AFC | 0.93 ± 0.33 | 0.87 ± 0.20 |
| AMH 24–40 pmol/L | ||
| AMH, median (IQR) | 33 (28–35) | 27 (24–29) |
| FSH, median (IQR) | 7.3 (6.6–8.0) | 6.0 (5.6–7.9) |
| AFC, mean ± SD | 27.5 ± 7.3 | 25.8 ± 7.5 |
| AMH/AFC | 1.22 ± 0.06 | 1.17 ± 0.4 |
AMH, anti-Müllerian hormone; AFC, antral follicle count. No statistical differences between groups using Student’s t-test, Mann–Whitney U test or Chi2-test as appropriate. *All serum AMH values in the present article are expressed as with the Elecsys assay.