Table II.
Clinical outcome by individualized AMH-based or standard dosing.
| Type of dosing | ||||
|---|---|---|---|---|
| Individualized | Standard | |||
| N = 146a | N = 71a | P | SMD 95% CI | |
| Follicles aspiratedb | 8.6 ± 3.5 | 9.0 ± 4.3 | 0.23e | −0.4 (−0.8 to 1.6) |
| Oocytes retrieved per pretreatment AMH (pmol/L) | ||||
| Low (AMH 4–11.99) | 7.3 ± 3.6 | 5.1 ± 3.3 | 0.04e | 2.2 (0.2 to 4.1) |
| Normal (AMH 12–23.99) | 8.1 ± 3.5 | 8.5 ± 3.3 | 0.58e | −0.4 (−1 to 1.8) |
| High (AMH 24–40) | 6.3 ± 3.5 | 10.6 ± 3.6 | 0.00e | −4.3 (−6.4 to −2.1) |
| Total | 7.5 ± 3.6 | 8.1 ± 3.9 | 0.25e | −0.6 (−0.5 to 1.7) |
| Oocytes retrieved | 0.68f | |||
| <5—unintended low | 34 (23.3) | 13 (18.3) | 0.51g | 5% (−7 to 17) |
| 5–14—intended | 105 (71.9) | 55 (77.5) | 0.48g | −6% (−19 to 8) |
| ≥15—unintended high | 7 (4.8) | 3 (4.2) | 0.98g | 0.6% (−6 to 9) |
| Duration of stimulation (d) | 8.8 ± 1.4 | 8.2 ± 1.3 | 0.00e | 0.6 (0.2 to 1.0) |
| Total FSH dose (IU)c | 1.177 ± 262 | 1.239 ± 166 | 0.09e | −62 (−23 to 111) |
| Fertilization | ||||
| Fertilized oocytes | 3.9 ± 2.5 | 3.7 ± 2.5 | 0.78e | 0.2 (−0.9 to 0.5) |
| Rate of fertilization | 54 ± 27 | 46 ± 28 | 0.04g | 8% (16 to 0.01) |
| Embryo development | ||||
| Embryos Day 2 | 4.1 ± 2.6 | 4.0 ± 2.7 | 0.82e | 0.1 (−0.9 to 0.6) |
| Blastocysts Day 5 | 1.9 ± 1.6 | 1.9 ± 1.9 | 0.57e | 0 (−0.5 to 0.5) |
| Blastocyst transfer | 122 (83.6) | 56 (78.9) | 0.40f | 4.7% (−8 to 17) |
| No transfer | 24 (16.4) | 15 (21.1) | ||
| OHSS any typed | 2/149 (1.3) | 2/72 (2.8) | 0.73g | 1.5% (−7 to 4) |
| Positive hCGd | 57/149 (38.3) | 32/72 (44.4) | 0.34g | −6.1% (−21 to 9) |
| Ongoing pregnancy (week 7)d | 44/149 (29.5) | 21/72 (29.2) | 0.79g | 0.3% (−13 to 14) |
| Live birthd | ||||
| Per fresh cycle | 41/149 (27.5) | 21/72 (29.2) | 0.79g | −1.7% (−15 to 12) |
| Per FET | 6/22 (27.3) | 4/7 (57.1) | 0.16g | −30% (−80 to 20) |
| Cumulative | 47/149 (31.5) | 25/72 (34.7) | 0.64g | −3.2% (−17 to 11) |
Values are mean ± SD and count (column %).
OHSS, ovarian hyperstimulation syndrome; FET, frozen embryo transfer; SMD, standardized mean difference.
aAnalyses for women who had oocyte retrieval. unless otherwise specified.
bMissing data on follicles aspirated (n = 8).
cFSH dose comparing medium and high pretreatment AMH-strata.
dIn the intention-to-treat population.
et-test.
fChi2-test.
gMann–Whitney U test