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. 2019 Feb 26;13:767–774. doi: 10.2147/DDDT.S179101

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© 2019 Guo et al. This work is published and licensed by Dove Medical Press Limited

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ER stress activator tunicamycin counteracts the effects of GB on I/R injury.

Notes: Sprague Dawley rats were divided into Sham, I/R, I/R+GB, I/R+TM, and I/R+GB+TM groups. (A, B) Relative expression of proteins was detected by Western blot. (C) HE staining of cardiac tissue. (D, E) Apoptosis was detected by TUNEL assay. (F, G) Levels of cTnI and cTnT in peripheral blood were detected and compared. The bars showed means±SD of three independent experiments. ^aP <0.5 compared with Sham group; ^bP <0.05 compared with I/R group; ^cP <0.05 compared with I/R+GB group.

Abbreviations: cTnI, cardiac troponin I; cTnT, cardiac troponin T; ER, endoplasmic reticulum; GB, ginkgolide B; I/R, ischemia reperfusion; TM, tunicamycin; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling.