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. 2019 Feb 26;13:767–774. doi: 10.2147/DDDT.S179101

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© 2019 Guo et al. This work is published and licensed by Dove Medical Press Limited

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GB exerts protective effects against I/R injury through activation of PI3K/AKT/mTOR pathway.

Notes: Sprague Dawley rats were divided into Sham, I/R, I/R+GB, I/R+LY294002, I/R+GB+LY294002 < I/R+AG490, and I/R+GB+AG490 groups. (A, B) Relative expression of proteins was detected by Western blot. (C, D) Levels of cTnI and cTnT in peripheral blood were detected and compared. The bars show means±SD of three independent experiments. ^aP <0.5 compared with Sham group; ^bP <0.05 compared with I/R group; ^cP <0.05 compared with I/R+GB group.

Abbreviations: cTnI, cardiac troponin I; cTnT, cardiac troponin T; GB, ginkgolide B; I/R, ischemia reperfusion.