Table 8.
Comparative maximum possible effect (%MPE; at 60 and 90 minutes) and AUC of various lidocaine-containing formulations
| Formulae | %MPE | AUC (seconds minutes) | |
|---|---|---|---|
| 60 minutes | 90 minutes | ||
| Lidocaine solution | 17.39±1.1 | 15.71±1.04 | 352.32±5.87 |
| Lidocaine-containing gel | 39.13±2.1 | 27.14±1.21 | 368.5±6.52 |
| Transfersomal lidocaine-containing gel | 59.42±1.89 | 52.86±1.30 | 446.1±4.89 |
| Transfersomal lidocaine-containing gel with PG | 63.76±1.5 | 60±2.30 | 494.1±5.51 |
| Transfersomal lidocaine-containing gel with DAMSO | 82.61±2.4 | 64.29±1.68 | 518.5±5.66 |
| Transfersomal lidocaine-containing gel with PAMAM G3 | 91.30±3.5 | 75.71±1.85 | 570.5±6.81 |
Abbreviations: PAMAM G3, polyamido amine dendrimer third generation; PG, propylene glycol; AUC, area under the curve.