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. 2019 Feb 26;12:1629–1640. doi: 10.2147/OTT.S196713

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© 2019 Gao et al. This work is published and licensed by Dove Medical Press Limited

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ARQ-197 decelerates the clearance of sorafenib in MHCC97-H cells.

Notes: (A) MHCC97-H cells, which were treated with IC₂₅ concentration sorafenib for 12 hours, were harvested at indicated time points. (B) Sorafenib solution was injected into subcutaneous tumor formed by MHCC97-H cells, and tumor tissues were harvested at indicated time points. Samples were analyzed by LC-MS/MS. Drugs clearance curve was calculated based on the sustaining of sorafenib in cells or tumors. ^*P<0.05.

Abbreviation: LC-MS/MS, liquid chromatography–mass spectrometry/mass spectrometry.