TABLE 2.

Binary Moderator Analysis: Treatment Effect at Both Levels of Each Binary Moderator Compares Mean Change in Uutcome (Either ADAS-Cog or SRT Total Immediate Recall) Between Donepezil and Placebo Groups, Adjusting for Baseline Outcome Value, Age, Site, Visit Week, and Intracranicl Volume for MRI Measures

Outcome Measure	Binary Moderator	Treatment Effect In ApoE e4 + or High-Volume Group Mean (SE); n	Treatment Effect In ApoE e4- or Low-Volume Group Mean (SE); n	Test Statistic & p Value for Interaction
ADAS-Cog	ApoE e4+ Status	2.53 (1.80); n = 21	1.19 (1.30); n = 39	F(1,93) = 0.38 p = 0.538
	Deep White Matter HI	4.24 (1.69);n = 23b	0.74 (1.59); n = 26	F(1,78) = 2.39 p = 0.126
	Periventricular HI	3.11 (1.69);n =24a	1.81 (1.66); n = 25	F(1,78) = 0.31 p = 0.576
	Subcortical Grey HI	8.00 (2.24);n = 12b	0.94 (1.20); n = 37	F(1,78) = 8.18 p = 0.005
	Total HI	3.49 (1.71);n = 24b	1.68 (1.63); n = 25	F(1,78) = 0.63 p = 0.432
SRT Total Immediate Recall	ApoE e4 Status	−0.52 (3.23); n = 21	1.51 (2.42); n = 39	F(1,94) = 0.27 p = 0.603
	Deep White HI	−4.92 (2.95); n =23a	6.35 (2.77);n = 26b	F(1,78) = 8.54 p = 0.005
	Periventricular HI	−2.65 (3.03); n = 24	4.99 (2.97);n =25a	F(1,78) = 3.52 p = 0.064
	Subcortical Grey HI	−3.89 (4.55); n = 12	2.39 (2.45); n = 37	F(1,77) = 1.60 p = 0.210
	Total HI	−2.95 (3.07); n = 24	5.03 (2.93);n =25a	F(1,78) = 3.86 p = 0.053

Notes: In the randomized sample, 50 patients had brain MRI, and assessment of HI could be conducted in 49 of these 50 patients. Tests for treatment effect within moderator subgroups are t-test contrasts estimated from the corresponding mixed-effects models. Degrees of freedom for each t-test are the same as the denominator degrees of freedom for each F statistic shown in the p value for interaction column. HI: Hyperintensity volume; SE: standard error.

^ap <0.10 for treatment effect within specified group.

^bp <0.05 for treatment effect within specified group.