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. 2019 Feb 11;10:61. doi: 10.3389/fgene.2019.00061

FIGURE 1.

FIGURE 1

Brain MRI image of the ASD proband. (A–D) Brain MRI of the ASD proband at 10 months of age (II-2). (A) T1-weighted sagittal image shows fully formed but diffusely thin corpus callosum. The cerebellar vermis is normal. (B) T1-weighted axial image reveals normal gyral pattern of cerebral cortex and diminished cerebral white matter volume. (C) T2-weighted axial image demonstrates delayed myelination at anterior limbs of both internal capsules and diffuse white matter abnormalities seen as T2W hyperintensity at periventricular and subcortical white matter. (D) T2-weighted coronal image shows more obvious mild cerebral atrophy seen as enlarged CSF space and prominent temporal horns of both lateral ventricles. Diffuse white matter abnormalities at periventricular and subcortical white matter are noted.