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. 2019 Feb 11;13:21. doi: 10.3389/fncel.2019.00021

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Copyright © 2019 Savini, Pardini, Castellazzi, Lascialfari, Chard, D’Angelo and Gandini Wheeler-Kingshott.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Boxplots representing the summary of clinical scores in the different groups of subjects. Statistically significant differences between groups are indicated with ^∗p < 0.05 and ^∗∗p < 0.01 according to results obtained with ANOVA post hoc tests or T-tests according to the specific case (see section “Statistical Analysis” and Table 2). It can be observed that SDMT and depression (HADS-D) are significantly different in MS patients and HC. EDSS and, to a lesser extent, disease duration and NART can discriminate between CIMS and CPMS.