Table 1.

Marketed butyrophenones with approval status and indication

Generic name	Trade name	Approved for human use?	Approved for use in the USA?	Notes
Azaperone	Azaperona, Stresnil, Fluoperidol, Suicalm, Eucalmyl, Sedaperone vet	No	Yes	Approved for veterinary use only
Benperidol	Anquil, Glianimon	Yes	No	Most potent neuroleptic on the European market; 150%–200% potency of haloperidol
Bromperidol	Brimidol, Bromodol, Erodium, Impromen	Yes	No	Only available in Belgium, German, the Netherlands, and Italy
Cinuperone		Yes	No
Droperidol	Droleptan, Dridol, Inapsine, Xomolix, Innovar (combination with fentanyl)	Yes	Yes	US FDA Black Box warning for torsade’s de pointesa
Fluanisone	Haloanison, Sedalande, Anti-Pica, Metorin	Yes	No	Veterinary use; used for agitation in humans, but no longer marketed; was available in Belgium, France, Germany, and Switzerland
Haloperidol	Haldol, Peridol	Yes	Yes
Lenperone	Elanone-V	Yes	No	Veterinary use
Moperone	Luvatren, Methylperidol, Meperon, Luvatrena	Yes	No	No longer available on market. Previously available in Japan, Sweden, and Switzerland
Nonaperone	Nonaperonum, Nonaperona	Yes	No	Only available in India.
Pipamperone	Dipiperone, Dipiperal, Piperonil, Piperonyl, Propitan	Yes	No	Also known by non-trade names including carpiperone and floropipamide or fluoropipamide, and as floropipamide hydrochloride
Spiperone	Spiroperidol, Spiropitan	Yes	No	Marketed in Japan
Timiperone	Tolopelon	Yes	No	Marketed in Japan
Trifluperidol	Psychoperidol, Triperidol, Trisedyl	Yes	No	Only available in India. Previously available in Belgium, France, Germany, Italy, and the UK

Notes:

^aIn 2001, the US FDA changed the labeling requirements for droperidol injection to include a Black Box Warning, citing concerns of QT prolongation and torsades de pointes. The evidence for this is disputed, with nine reported cases of torsades de pointes in 30 years and all of those having received doses more than 5 mg. QT prolongation is a dose-related effect, and it appears that droperidol is not a significant risk in low doses. A study in 2015 showed that droperidol is relatively safe and effective for the management of violent and aggressive adult patients in hospital emergency departments in doses of 10 mg and above and that there was no increased risk of QT prolongation and torsades de pointes.

Abbreviation: US FDA, United States Food and Drug Administration.