Table 3.

Summary of the clinical effects of neuroleptanalgesia in patients with acute abdominal pain

Variable	Emergency department	Postoperative
Study	Roldan (2017)83	Sharma (1993)82	Laffey (2002)79	Liu (2003)80	Lo (2005)81	Oliviera (2013)78
Butyrophenone	Haloperidol	Droperidol	Droperidol	Droperidol	Droperidol	Haloperidol
Comparison	Standard care	Morphine	Morphine	Tramadol	Morphine	Dexamethasone Ondansetron
Pain intensity	↓			NC	↓	↓a
Patient satisfaction	NC	↑
Opiate consumption		NC	NC	NC	↓	↓
ED admission	↓
ED LOS	NC
Extrapyramidal side effects		NC	NC		NC
Nausea	↓	↓	NC	Early – ↓ Late – NC	Early – ↓ Late – NC	↓
Vomiting		↓	NC	Early – ↓ Late – NC	Early – ↓ Late – NC	NC
Sedation		NC	NC	NC

Notes: NC means no change.

^aThe Haldol + dexamethasone + ondansetron group had improved pain scores compared to ondansetron alone (P=0.046), but no change compared to dexamethasone + ondansetron group (P=0.052).