Figure 3.

Genes derived from airway basal cells are associated with high mortality in idiopathic pulmonary fibrosis. Based on the gene expression data from the Freiburg cohort, we found 165 genes highly expressed by airway basal cells predictive of mortality. (A) By componentwise likelihood-based boosting, we developed a prediction model in the Freiburg cohort. The prediction model based on the gene expression data of airway basal cell genes was validated in the Leuven cohort (B) and in the Siena cohort (C) and statistically significantly separated between mortality in both cohorts.