Table 1.
Baseline Characteristics of Patients with IPF
| Characteristic | All IPF (n = 176) | Freiburg (n = 62) | Leuven (n = 64) | Siena (n = 50) | P Value* |
|---|---|---|---|---|---|
| Age, yr | 68.1 ± 9.5 | 67.4 ± 9.1 | 68.2 ± 8.5 | 68.7 ± 11.2 | 0.768 |
| Male sex, % | 82 | 85 | 80 | 80 | 0.648 |
| FVC % predicted value, % | 71 ± 21 | 66 ± 20 | 78 ± 18 | 67 ± 23 | <0.001 |
| DlCO | |||||
| Percent predicted value, % | 43 ± 14 | 44 ± 16 | 45 ± 12 | 40 ± 15 | 0.396 |
| Could not perform DlCO, n | 20 | 7 | 1 | 12 | |
| Deaths, n (%) | 100 (57) | 45 (73) | 24 (38) | 31 (62) | |
| Transplants, n (%) | 10 (6) | 3 (5) | 3 (5) | 4 (8) | 0.704 |
| Median observation time, mo | 20 | 18 | 16 | ||
| Smoking status, % | 0.156 | ||||
| Never smoked | 33 | 42 | 23 | 34 | |
| Former smoker | 64 | 56 | 70 | 64 | |
| Current smoker | 3 | 2 | 6 | 2 | |
| HRCT UIP, n (%) | 0.208 | ||||
| Definite | 134 (76) | 43 (69) | 53 (83) | 38 (76) | |
| Possible | 42 (24) | 19 (31) | 11 (17) | 12 (24) | |
| HRCT emphysema present, n | 24 (14) | 5 (8) | 16 (25) | 3 (6) | |
| BAL | |||||
| Cell count, ×106 cells | 13.0 ± 7.7 | 12.1 ± 7.2 | 13.3 ± 8.8 | 13.7 ± 6.9 | 0.518 |
| Alveolar macrophages, % | 74 ± 17 | 71 ± 17 | 80 ± 17 | 71 ± 16 | 0.006 |
| Lymphocytes, % | 10 ± 9 | 11 ± 9 | 9 ± 10 | 10 ± 9 | 0.358 |
| Neutrophils, % | 11 ± 14 | 12 ± 14 | 9 ± 14 | 13 ± 14 | 0.192 |
| Eosinophils, % | 4 ± 5 | 4 ± 5 | 3 ± 4 | 5 ± 6 | 0.128 |
Definition of abbreviations: HRCT = high-resolution computed tomography; IPF = idiopathic pulmonary fibrosis; UIP = usual interstitial pneumonia.
Data are mean ± SD unless otherwise indicated.
*
Group comparison by ANOVA for continuous and chi-square test for categorical characteristics.