2. Diagnostic criteria for myocardial infarction.
| Study | Criteria |
| Aguero‐Martinez 2012 | New pathological Q wave (duration ≥ 0.04 second and depth ≥ 25% of the R wave or QRS complex) in more than 1 derivation. Non‐specific changes that included elevation of the ST segment > 1.5 mm from the isoelectric line in 2 or more leads of the same region, ST depression > 2 mm in the precordial leads, or reversal of the T wave for longer than 48 hours; absence of R wave in the precordial leads. Ventricular or atrioventricular conduction defects Enzymatic criteria: 5 times normal values: troponin > 1 mcg/mL, CK > 250 U/L, CK‐MB > 133 U/L, LDH > 800 U/L, LDH 1/LDH 2 > 1 in blood samples collected between postoperative days 2 and 3, and GOT > 90 U/L Echocardiographic criteria: new segmental motility disorders Anatomopathological criteria: in dead patients |
| Bakhtiary 2007 | Unspecified |
| Barrington 2005 | Transmural infarction defined as new Q waves |
| Bektas 2015 | 1. Cardiac biomarkers (with troponins preferred) rise > 10 times 99% upper reference limit (URL) from normal preoperative level 2. New pathological Q waves or new left bundle branch block (LBBB) and/or imaging or angiographic evidence of new occlusion of native vessels or grafts, new regional wall motion abnormality, or loss of viable myocardium |
| Caputo 2011 | New Q waves of 0.04 ms and/or reduction in R waves > 25% in at least 2 contiguous leads on ECG |
| Celik 2015 | ECG monitored (ST analysis); CK‐MB and troponin I levels measured at fourth and 24th hours |
| de Vries 2002 | Myocardial infarction defined as a new Q wave on ECG and CK 180 U/L with CK‐MB 10% of total |
| Dohle 2001 | Myocardial infarction assessed by ECG changes and CK‐MB values |
| Fillinger 2002 | New Q waves of at least 0.04 second duration or postoperative elevation of serum creatine phosphokinase confirmed by creatine phosphokinase isoenzyme pattern |
| Hansdottir 2006 | New Q waves or CK‐MB isoenzyme concentration ≥ 50 |
| Heijmans 2007 | Myocardial infarction not mentioned in the report |
| Jakobsen 2012 | Perioperative myocardial infarction, defined as new Q waves of 0.04 ms and/or reduction in R waves > 25% in at least 2 contiguous leads on ECG |
| Kendall 2004 | ECG changes (new Q wave, or loss of R wave progression, or new permanent left bundle branch block) and increase in creatinine kinase myocardial fraction (CK‐MB) to > 120 units per litre |
| Kilickan 2006 | Unspecified |
| Liem 1992 | CK‐MB values ≥ 80 IU/L and evidence of new Q waves or bundle branch block on postoperative ECG |
| Loick 1999 | Unclear |
| Lyons 1998 | Unclear |
| Mehta 1998 | Incidence of perioperative myocardial infarction also analysed by an independent cardiologist, as per the appearance of new Q waves in the ECG and increase in creatine phosphokinase‐myocardial band isoenzyme (CPK‐MB) levels to > 70 ng/mL in the first 12 hours postoperatively |
| Mehta 2010 | 2‐lead ECG and CPK, CPK‐MB levels |
| Neskovic 2013 | New ECG changes with positive enzymes (CK‐MB and troponin) |
| Obersztyn 2018 | ECG and elevated serum enzymes |
| Onan 2011 | Unspecified |
| Onan 2013 | Unspecified |
| Palomero 2008 | Myocardial infarction defined by analysis of the ECG (new Q waves or increases in ST segment > 3 mm) |
| Priestley 2002 | New Q waves (assessed by the blinded cardiologist) on a 12‐lead ECG on days 0, 1, 2, and 4 and assessment of venous blood levels of troponin T and creatine kinase‐MB fraction on arrival in the ICU, and again at 4, 12, and 24 hours and on postoperative day 2 |
| Scott 2001 | Q waves, ST segment increase of 3 mm, and a myocardial specific serum creatinine kinase level ≥ 60 ng/mL |
| Stenseth 1994 | Unspecified |
| Stenseth 1996 | Unspecified |
| Svircevic 2011 | Creatine kinase muscle–brain isoenzymes > 75 units per litre (5 times upper limit of normal level) and peak creatine kinase muscle–brain isoenzyme/creatine kinase ratio > 10% or new Q wave infarction |
| Zawar 2015 | Myocardial infarction defined as developing ECG changes, new Q waves on postoperative ECG ≥ 0.03 second in duration in 2 or more adjacent leads lasting until discharge, rise in creatine phosphokinase‑MB and troponin I, and new regional wall motion abnormalities |
CK: creatinine kinase; CK‐MB: creatinine kinase muscle brain; ECG: electrocardiogram; GOT: glutamic‐oxaloacetic transaminase; LBBB: left bundle branch block; LDH: lactate dehydrogenase; URL: upper reference limit.