Kilickan 2006.

Methods	Parallel RCT Ethics committee: approved by the institutional review committee Informed consents: patient consents were obtained Site: Kocaeli University School of Medicine, Kocaeli, Turkey Setting: university hospital Dates of data collection: unspecified Funding: unspecified Registration: unspecified
Participants	80 participants; mean age: 59.9 years; sex distribution: 16 females and 64 males Inclusion criteria Undergoing elective CABG with CPB Exclusion criteria Compromised coagulation (thromboplastin time < 80%, prothrombin time > 40 seconds, or platelets < 100 nL)
Interventions	Intervention Epidural analgesia with LVEF ≤ 0.4 (N = 20) or > 0.4 (N = 20) Comparator Systemic analgesia with LVEF ≤ 0.4 (N = 20) or > 0.4 (N = 20) Premedication: midazolam Induction: midazolam, fentanyl, and vecuronium Maintenance: nitrous oxide, propofol, and fentanyl Suregry: CABG with CPB
Outcomes	Relevant to this review Risk of mortality Risk of myocardial infarction Risk of atrial fibrillation or atrial flutter Tracheal extubation Pain scores Haemodynamic variables Other Right atrial biopsies
Notes	Correspondence: email sent 16 March 2018; no reply Conflict of interest: not reported DOI: n/a
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomly distributed sealed envelopes
Allocation concealment (selection bias)	Low risk	Sealed envelopes
Blinding of participants and personnel (performance bias) All outcomes	High risk	Study was not blinded
Blinding of outcome assessment (detection bias) All outcomes	High risk	Study was not blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	No loss to follow‐up
Selective reporting (reporting bias)	Low risk	All results reported
Other bias	Low risk	No failed epidural Groups well balanced