Skip to main content
. 2019 Feb 25;14:1503–1517. doi: 10.2147/IJN.S193976

Figure 5.

Figure 5

Enhanced drug penetration of PL/ACC-MIT nanoparticles in tumor tissue.

Notes: (A) In vitro penetration of MIT into the MCTS after incubation with free MIT or PL/ACC-MIT nanoparticles for 24 hours. (B) In vivo penetration of nanoparticles into the tumor tissue after intratumoral injection of free MIT or PL/ACC-MIT nanoparticles for 24 hours. The frozen tumor sections were observed from the top (injection site) of the tumor to the middle using CLSM. The nuclei were stained by DAPI (blue). Scale bar: 200 µm.

Abbreviations: ACC, amorphous calcium carbonate; CLSM, confocal laser scanning microscopy; MCTS, multicellular tumor spheroid; MIT, mitoxantrone; PL, phospholipid.