Fig 3. Dependence of the dead zone length on the Michaelis constant for nuclear protein degradation K_m.

(A) Phase sensitivity –Z_z and (B) time series of the levels of nuclear protein z for different values of K_m. (C) Dead zone length L_d (top) and the maximum and minimum values of the phase sensitivity –Z_z^(max) and –Z_z^(min) (bottom) as a function of K_m. In (A) and (C), the phase sensitivity is normalized by the period of oscillation T_p. (D) Time series of transcription rate 1/(1+(z/K₁)ⁿ) in Eq (1) for different values of K_m. Values of reaction parameters are listed in S1 Table.