Fig 4. Implementation of an inhibition of viral mRNA synthesis improves description of viral mRNA dynamics.

(A) Model fits to viral mRNA measurements of MDCK cultures infected with influenza A/PR/8/34 (H1N1) at an MOI of 73 based on TCID₅₀ [4]. Error bars indicate standard deviations of three individual experiments. (B) Percentage of viral mRNA synthesis rate for different model versions, experimental data were adapted from [27]. In short, BHK-21 cells were infected by influenza virus (WSN strain) at 10 to 20 PFU per cell.