Table 3.

Pooled odds ratio for APOE ε4 allele in meta-analyses

Gene model	Gene formula	Pooled OR(95%CI)	Z score	P-value a	P-value b	P-value c	I 2
Allele	ε4 vs. ε2+ε3	1.36(1.11-1.66)	2.95	0.003	0.047	0.07	46%
Dominant	ε4/ε4+ε4/ε3+ε4/ε2 vs. ε2/ε3+ε2/ε2+ε3/ε3	1.34(1.06-1.68)	2.44	0.001	0.146	0.23	25%
Recessive	ε4/ε4 vs. ε2/ε2+ε2/ε3ε+ε3/ε3+ε2/ε4+ε3/ε4	1.11(0.45-2.76)	0.23	0.82	0.874	0.86	0%

OR: odd ratio; CI: confidence interval

^a: Fix effect model was used in the meta-analysis to calculate Z score, P<0.05 was considered statistically significant.

^b: Egger’s test to assess publication bias, P<0.05 was considered potential publication bias.

^c: Heterogeneity test was assess using Cochran’s (Q) x² test, P<0.01 was considered potential heterogeneity.