Table 1.
Variable | All (N=2846) | Short (< 6.5 H) (N=1119) | Normal (≥ 6.5 to < 7.5 H) (N=741) | Long (≥ 7.5 H) (N=986) | Overall P-value | P-value for pairwise comparison |
||
---|---|---|---|---|---|---|---|---|
Normal vs short | Normal vs long | Short vs long | ||||||
Age (years) | 64 ± 13 | 62 ± 12 | 64 ± 12 | 66 ± 13 | <0.001 | 0.006 | <0.001 | <0.001 |
Women | 1071 (38%) | 472 (42%) | 254 (34%) | 345 (35%) | <0.001 | 0.001 | 0.76 | 0.001 |
Black | 642 (23%) | 372 (33%) | 124 (17%) | 146 (15%) | <0.001 | <0.001 | 0.28 | <0.001 |
Body mass index (kg/m2) | 30 ± 6 | 31 ± 7 | 30 ± 6 | 29 ± 6 | <0.001 | <0.001 | 0.61 | <0.001 |
Hypertension | 2427 (85%) | 968 (87%) | 624 (84%) | 836 (85%) | 0.37 | 0.20 | 0.80 | 0.27 |
Diabetes mellitus | 1064 (38%) | 441 (40%) | 258 (35%) | 365 (37%) | 0.13 | 0.05 | 0.34 | 0.27 |
Hyperlipidemia† | 2139 (75%) | 838 (75%) | 535 (72%) | 766 (78%) | 0.04 | 0.17 | 0.01 | 0.17 |
Smoker | 2067 (73%) | 800 (72%) | 522 (70%) | 745 (76%) | 0.03 | 0.63 | 0.02 | 0.04 |
Prior MI | 642 (23%) | 241 (22%) | 149 (21 %) | 252 (26%) | 0.02 | 0.46 | 0.01 | 0.04 |
Heart failure | 987 (35%) | 412 (37%) | 230 (31%) | 345 (35%) | 0.04 | 0.01 | 0.09 | 0.38 |
Ejection fraction (%) | 53 ± 12 | 53 ± 13 | 54 ± 11 | 52 ± 13 | 0.01 | 0.04 | 0.02 | 0.88 |
Gensini score, points | 86 [2,240] | 80 [0,234] | 85 [2,244] | 112 [4,256] | 0.07 | 0.91 | 0.83 | 0.06 |
Obstructive CAD‡ | 2082 (82%) | 792 (81%) | 542 (81%) | 748 (84%) | 0.20 | 0.68 | 0.24 | 0.08 |
Acute MI at enrollment | 228 (8%) | 90 (8%) | 60 (8%) | 78 (8%) | 0.99 | 0.97 | 0.89 | 0.97 |
Revascularization at enrollment | 941 (33%) | 373 (33%) | 253 (34%) | 315 (32%) | 0.61 | 0.72 | 0.34 | 0.50 |
All-cause death | 412 (15%) | 166 (15%) | 81 (11%) | 165 (17%) | 0.003 | 0.02 | 0.001 | 0.05 |
Cardiovascular death | 251 (9%) | 111 (10%) | 50 (7%) | 90 (9%) | 0.06 | 0.02 | 0.07 | 0.77 |
Myocardial infarction | 107 (4%) | 42 (4%) | 22 (3%) | 43 (4%) | 0.32 | 0.36 | 0.13 | 0.99 |
Coronary revascularization | 587 (21%) | 236 (21%) | 150 (20%) | 201 (20%) | 0.88 | 0.66 | 0.94 | 0.73 |
Stroke | 68 (2%) | 25 (2%) | 18 (2%) | 25 (3%) | 0.90 | 0.78 | 0.89 | 0.65 |
Values are mean (SD), median [25th and 75th interquartile range], or n (%).
Defined by physician diagnosis in medical charts
Obstructive coronary artery disease (CAD) is defined by the presence of ≥50% obstructive lesion in any of the major epicardial vessels on coronary angiography at enrollment.
Abbreviations: MI = myocardial infraction; CAD = coronary artery disease