Fig. 4.

Infection of C57BL/6J is enhanced by PAR2 deficiency. Wild type C57BL/6J mice inoculated with either TF competent (TF+, n=7, grey bar, as in Fig. 3, TF+) or deficient (TF−; n=8, grey bar, as in Fig. 3, TF−) HSV1 via the tail vein were compared to PAR2 KO (PAR2−; n=6) mice and the combined effect of PAR2 knock out and viral TF-deficiency (n=5). Three days post-inoculation, the mice were processed and the amount of infectious virus (Virus; PFU/mg) or genome copies (Genome; genome copies/mg) was determined. In all panels data are expressed as mean ± SEM. As determined by Student’s t test, **P ≤ 0.05 and *P ≤ 0.10 and when compared to the TF+ virus except for the TF−/PAR2− which is compared to the TF− virus.