Table 4. Objective Olfactory Assessment of All CRS Patients (Age-Sex Adjusted SIT)-Multivariate Model.

CRS = chronic rhinosinusitis; CRSsNP = chronic rhinosinusitis without nasal polyps; CRSwNP = chronic rhinosinusitis with nasal polyps; CT = computed tomography; SIT score = smell identification test score; tissue eos/HPF = tissue eosinophils per high power field; NCS = nasal corticosteroid medication use; anti-leukotriene = anti-leukotriene nasal medication use; AERD = aspirin exacerbated respiratory disease; AFRS = allergic fungal rhinosinusitis; IL = interleukin; RANTES = regulated on activation, normal T cell expressed and secreted; TNF = tumor necrosis factor BOLD, P< .05

Multivariate Regression				Collinearity Statistics
Variables	Adjusted β	95% CI	p value	VIF
Age	Not Modeled	*	*	*
Sex	Not Modeled	*	*	*
Asthma	0.726	−3.366 to 4.818	0.725	1.47
Allergic Rhinitis	Not Modeled	*	*	*
AERD	−9.102	−16.385 to −1.820	0.015	1.79
Current Smoker	Not Modeled	*	*	*
NCS	1.942	−2.522 to 6.336	0.39	1.15
Anti-Leukotriene	1.913	−2.511 to 6.336	0.393	1.31
Prior Surgery	−1.623	−5.464 to 2.218	0.404	1.24
Eos/HPF (mean)	−0.007	−0.024 to 0.010	0.418	1.44
Neu/HPF (mean)	Not Modeled	*	*	*
Culture(+) Purulence	Not Modeled	*	*	*
CT Score	−0.569	−1.019 to −0.118	0.014	1.93
Polyp Status/Phenotype	−4.123	−8.844 to 0.598	0.086	1.98
AFRS	−1.959	−8.319 to 4.402	0.542	1.58
IL-1β	Not Modeled	*	*	*
IL-2	−0.014	−0.024 to −0.004	0.005	1.11
IL-4	Not Modeled	*	*	*
IL-5	−0.004	−0.017 to 0.009	0.547	4.51
IL-6	Not Modeled	*	*	*
IL-7	Not Modeled	*	*	*
IL-8	Not Modeled	*	*	*
IL-9	Not Modeled	*	*	*
IL10	Not Modeled	*	*	*
IL-12/I-23p40	Not Modeled	*	*	*
IL-13	0.004	−0.028 to 0.036	0.802	5.62
IL-17α	Not Modeled	*	*	*
IL-21	Not Modeled	*	*	*
TNFα	Not Modeled	*	*	*
IFNγ	Not Modeled	*	*	*
Eotaxin	−0.010	−0.040 to 0.021	0.525	1.38
RANTES	Not Modeled	*	*	*