Figure 2.

3D structure of the tau protein at serine and threonine sites. Tau regulated by four main kinase enzymes: cyclin-dependent kinase, protein kinase A, protein kinase C and calmodulin-dependent protein kinase. (a) The kinase-dependent regulated site of serine and threonine residue locations on a 3D structure of tau (highlighted in orange), and (b) the full-length tau protein consists of an acidic, proline-rich domain and a microtubule-binding repeat domain. See the four kinase-targeting locations of tau (highlighted on the protein model of tau).