This scoping review provides an overview of all instruments that have been used to assess health-related quality of life (HRQoL) after transplantation. This overview will be useful in the process of instrument selection in future studies.

Generic instruments are the most frequently applied HRQoL instruments in solid organ transplantation studies. Despite the availability of transplant-specific instruments, only a few studies have applied these types of instruments to measure HRQoL in transplant patients.

There is a need to develop a preference-based, transplant-specific HRQoL instrument. Such an instrument should be easy to apply, and its content should target the health issues of solid organ recipients from the patient perspective.